Giants and monsters: Unexpected characters in the story of cancer recurrence
S White-Gilbertson, C Voelkel-Johnson - Advances in cancer research, 2020 - Elsevier
Polyploid giant cancer cells (PGCC) constitute a dangerous subpopulation of cancer cells
and are a driving force in cancer recurrence. These unique cells arise from diploid tumor
cells in response to stress encountered in the tumor microenvironment or during cancer
therapy. PGCC are greatly dedifferentiated, acquire pluripotency, and are able to replicate
through a form of asymmetric division called neosis, which results in new populations that
are themselves able to differentiate into new cell types or to re-establish tumors. Progeny …
and are a driving force in cancer recurrence. These unique cells arise from diploid tumor
cells in response to stress encountered in the tumor microenvironment or during cancer
therapy. PGCC are greatly dedifferentiated, acquire pluripotency, and are able to replicate
through a form of asymmetric division called neosis, which results in new populations that
are themselves able to differentiate into new cell types or to re-establish tumors. Progeny …