Induction chemotherapy followed by concurrent radio-chemotherapy versus concurrent radio-chemotherapy alone as treatment of locally advanced squamous cell …
Background Induction chemotherapy with docetaxel, cisplatin and 5 FU (TPF) before
radiotherapy (RT) or radio-chemotherapy (RT-CHX) has been shown to improve overall
survival (OS) compared to induction chemotherapy with cisplatin and 5 FU in locally
advanced squamous cell carcinoma of the head and neck (HNSCC). Whether TPF induction
before RT-CHX improves clinical outcome in comparison with RT-CHX alone is still a matter
of debate. Recently, the results of 5 randomized trials addressing this question have become …
radiotherapy (RT) or radio-chemotherapy (RT-CHX) has been shown to improve overall
survival (OS) compared to induction chemotherapy with cisplatin and 5 FU in locally
advanced squamous cell carcinoma of the head and neck (HNSCC). Whether TPF induction
before RT-CHX improves clinical outcome in comparison with RT-CHX alone is still a matter
of debate. Recently, the results of 5 randomized trials addressing this question have become …