[HTML][HTML] Translational analysis of mouse and human placental protein and mRNA reveals distinct molecular pathologies in human preeclampsia

B Cox, P Sharma, AI Evangelou, K Whiteley… - Molecular & Cellular …, 2011 - ASBMB
Preeclampsia (PE) adversely impacts∼ 5% of pregnancies. Despite extensive research, no
consistent biomarkers or cures have emerged, suggesting that different molecular
mechanisms may cause clinically similar disease. To address this, we undertook a
proteomics study with three main goals:(1) to identify a panel of cell surface markers that
distinguish the trophoblast and endothelial cells of the placenta in the mouse;(2) to translate
this marker set to human via the Human Protein Atlas database; and (3) to utilize the …