Adriana and Luisa Castellucci Award Lecture 2001 Hypoxia Inducible Factor-1: Oxygen regulation of trophoblast differentiation in normal and pre-eclamptic …
I Caniggia, JL Winter - Placenta, 2002 - Elsevier
During early pregnancy, trophoblast differentiation occurs in an environment of relative low
oxygen tension which is essential for normal embryonic and placental development. At
around 10–12 weeks' gestation, when the intervillous space opens to maternal blood, there
is an increase in Po2. This increase correlates with the time of maximal trophoblast invasion
into the maternal decidua, which allows extravillous trophoblast cells to access and remodel
the maternal spiral arteries. Hypoxia Inducible Factor 1 (HIF-1) is a transcription factor which …
oxygen tension which is essential for normal embryonic and placental development. At
around 10–12 weeks' gestation, when the intervillous space opens to maternal blood, there
is an increase in Po2. This increase correlates with the time of maximal trophoblast invasion
into the maternal decidua, which allows extravillous trophoblast cells to access and remodel
the maternal spiral arteries. Hypoxia Inducible Factor 1 (HIF-1) is a transcription factor which …