The immune response to coagulation factors VIII or IX, in particular formation of inhibitory
antibodies, complicates treatment of hemophilia. Therefore, a number of recent studies in
animal models have explored novel approaches toward induction of immune tolerance in
protein or gene replacement therapy. Strong evidence has emerged that regulatory T cells
(Treg) are an important component of the mechanism by which tolerance is maintained and
inhibitor formation, a T help dependent response, is prevented. Limited data in patients also …