Comprehensive immunohistochemical analysis of histone deacetylases in pancreatic neuroendocrine tumors: HDAC5 as a predictor of poor clinical outcome
E Klieser, R Urbas, S Stättner, F Primavesi, T Jäger… - Human pathology, 2017 - Elsevier
Epigenetic factors contribute to carcinogenesis, tumor promotion, and chemoresistance.
Histone deacetylases (HDACs) are epigenetic regulators that primarily cause chromatin
compaction, leading to inaccessibility of promoter regions and eventually gene silencing.
Many cancer entities feature overexpression of HDACs. Currently, the role of HDACs in
pancreatic neuroendocrine tumors (pNETs) is unclear. We analyzed the expression patterns
of all HDAC classes (classes I, IIA, IIB, III, and IV) in 5 human tissue microarrays representing …
Histone deacetylases (HDACs) are epigenetic regulators that primarily cause chromatin
compaction, leading to inaccessibility of promoter regions and eventually gene silencing.
Many cancer entities feature overexpression of HDACs. Currently, the role of HDACs in
pancreatic neuroendocrine tumors (pNETs) is unclear. We analyzed the expression patterns
of all HDAC classes (classes I, IIA, IIB, III, and IV) in 5 human tissue microarrays representing …