[HTML][HTML] Neutralizing IL-17 prevents obliterative bronchiolitis in murine orthotopic lung transplantation
L Fan, HL Benson, R Vittal, EA Mickler… - American journal of …, 2011 - Elsevier
Obliterative bronchiolitis (OB) is the key impediment to the long-term survival of lung
transplant recipients and the lack of a robust preclinical model precludes examining OB
immunopathogenesis. In the current study, lungs from C57BL/10 H-2 b mice that are MHC
compatible, but minor histocompatability antigen incompatible, were transplanted into
C57BL/6 mice. Histological features and cytokine profiles of OB were assessed. Moderate
rejection (grade A3) developed by day 14, with evidence of OB at that time point. At 21 days …
transplant recipients and the lack of a robust preclinical model precludes examining OB
immunopathogenesis. In the current study, lungs from C57BL/10 H-2 b mice that are MHC
compatible, but minor histocompatability antigen incompatible, were transplanted into
C57BL/6 mice. Histological features and cytokine profiles of OB were assessed. Moderate
rejection (grade A3) developed by day 14, with evidence of OB at that time point. At 21 days …