[HTML][HTML] TNFα promotes mucosal wound repair through enhanced platelet activating factor receptor signaling in the epithelium

D Birkl, M Quiros, V García-Hernández, DW Zhou… - Mucosal …, 2019 - Elsevier
Pathobiology of several chronic inflammatory disorders, including ulcerative colitis and
Crohn's disease is related to intermittent, spontaneous injury/ulceration of mucosal surfaces.
Disease morbidity has been associated with pathologic release of the pro-inflammatory
cytokine tumor necrosis factor alpha (TNFα). In this report, we show that TNFα promotes
intestinal mucosal repair through upregulation of the GPCR platelet activating factor receptor
(PAFR) in the intestinal epithelium. Platelet activating factor (PAF) was increased in healing …