RvE1 uses the LTB4 receptor BLT1 to increase [Ca2+] i and stimulate mucin secretion in cultured rat and human conjunctival goblet cells
Purpose Specialized pro-resolving lipid mediator resolvin (Rv) E1 stimulates secretion
including mucins from conjunctival goblet cells. RvE1 can use both its ChemR23 receptor
and the LTB 4 receptor BLT1 to increase [Ca 2+] i. The purpose of this study was to
determine the expression of ChemR23 and BLT1 and receptors on conjunctival goblet cells
and the respective roles these two receptors play in goblet cell responses to RvE1. Methods
Goblet cells were cultured from male rat or human conjunctiva from both sexes. Western …
including mucins from conjunctival goblet cells. RvE1 can use both its ChemR23 receptor
and the LTB 4 receptor BLT1 to increase [Ca 2+] i. The purpose of this study was to
determine the expression of ChemR23 and BLT1 and receptors on conjunctival goblet cells
and the respective roles these two receptors play in goblet cell responses to RvE1. Methods
Goblet cells were cultured from male rat or human conjunctiva from both sexes. Western …