Vogt-koyanagi-harada disease
GAD O'Keefe, NA Rao - Survey of Ophthalmology, 2017 - Elsevier
Abstract Vogt-Koyanagi-Harada disease, a severe bilateral granulomatous intraocular
inflammation associated with serous retinal detachments, disk edema, and vitritis, with
eventual development of a sunset glow fundus, is an autoimmune inflammatory condition
mediated by T cells that target melanocytes in individuals susceptible to the disease. Vogt-
Koyanagi-Harada disease presents clinically in 4 different phases: prodromal, uveitic,
convalescent, and recurrent, with extraocular manifestations including headache …
inflammation associated with serous retinal detachments, disk edema, and vitritis, with
eventual development of a sunset glow fundus, is an autoimmune inflammatory condition
mediated by T cells that target melanocytes in individuals susceptible to the disease. Vogt-
Koyanagi-Harada disease presents clinically in 4 different phases: prodromal, uveitic,
convalescent, and recurrent, with extraocular manifestations including headache …
[HTML][HTML] Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes
MM Lavezzo, VM Sakata, C Morita… - Orphanet Journal of …, 2016 - Springer
Abstract Vogt-Koyanagi-Harada disease (VKHD) is a rare granulomatous inflammatory
disease that affects pigmented structures, such as eye, inner ear, meninges, skin and hair.
This disease is mainly a Th1 lymphocyte mediated aggression to melanocytes after a viral
trigger in the presence of HLA-DRB1* 0405 allele. The absence of ocular trauma or previous
intraocular surgery sets VKHD appart from sympathetic ophthalmia, its main differential
diagnosis. The disease has an acute onset of bilateral blurred vision with hyperemia …
disease that affects pigmented structures, such as eye, inner ear, meninges, skin and hair.
This disease is mainly a Th1 lymphocyte mediated aggression to melanocytes after a viral
trigger in the presence of HLA-DRB1* 0405 allele. The absence of ocular trauma or previous
intraocular surgery sets VKHD appart from sympathetic ophthalmia, its main differential
diagnosis. The disease has an acute onset of bilateral blurred vision with hyperemia …