IL-23 promotes CD4+ T cells to produce IL-17 in Vogt-Koyanagi-Harada disease
W Chi, P Yang, B Li, C Wu, H Jin, X Zhu, L Chen… - Journal of allergy and …, 2007 - Elsevier
BACKGROUND: Vogt-Koyanagi-Harada (VKH) disease is a systemic refractory autoimmune
disease. IL-23 has been thought to play a critical role in autoimmune disease through
inducing the development of IL-17–producing CD4+ T cells. OBJECTIVE: To investigate the
expression of IL-23 and IL-17 and the influence of IL-23 on IL-17 production in patients with
VKH disease. METHODS: Blood samples were taken from 25 patients with VKH disease and
16 healthy controls. Peripheral blood mononuclear cells (PBMCs) were subjected to …
disease. IL-23 has been thought to play a critical role in autoimmune disease through
inducing the development of IL-17–producing CD4+ T cells. OBJECTIVE: To investigate the
expression of IL-23 and IL-17 and the influence of IL-23 on IL-17 production in patients with
VKH disease. METHODS: Blood samples were taken from 25 patients with VKH disease and
16 healthy controls. Peripheral blood mononuclear cells (PBMCs) were subjected to …