Individuals age> 65 years old are the fastest expanding population demographic throughout
the developed world. Consequently, more aged patients than before are receiving
diagnoses of impaired renal function and nephrosclerosis—age–associated histologic
changes in the kidneys. Recent studies have shown that the aged kidney undergoes a
range of structural changes and has altered transcriptomic, hemodynamic, and physiologic
behavior at rest and in response to renal insults. These changes impair the ability of the …