Protein disulfide isomerase–endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness
SM Hoffman, DG Chapman, KG Lahue… - Journal of Allergy and …, 2016 - Elsevier
Background Evidence for association between asthma and the unfolded protein response is
emerging. Endoplasmic reticulum resident protein 57 (ERp57) is an endoplasmic reticulum–
localized redox chaperone involved in folding and secretion of glycoproteins. We have
previously demonstrated that ERp57 is upregulated in allergen-challenged human and
murine lung epithelial cells. However, the role of ERp57 in asthma pathophysiology is
unknown. Objectives Here we sought to examine the contribution of airway epithelium …
emerging. Endoplasmic reticulum resident protein 57 (ERp57) is an endoplasmic reticulum–
localized redox chaperone involved in folding and secretion of glycoproteins. We have
previously demonstrated that ERp57 is upregulated in allergen-challenged human and
murine lung epithelial cells. However, the role of ERp57 in asthma pathophysiology is
unknown. Objectives Here we sought to examine the contribution of airway epithelium …