[HTML][HTML] Increased expression of senescence-associated cell cycle inhibitor p16INK4a in deteriorating renal transplants and diseased native kidney
A Melk, BMW Schmidt, A Vongwiwatana… - American Journal of …, 2005 - Elsevier
Some features of kidney transplants with dysfunction overlap the lesions of aging, such as
tubular atrophy and interstitial fibrosis (TA/IF) without major glomerular abnormalities.
Somatic cell limitations could contribute to deterioration in aging and disease states. Since
expression of p16 INK4a, a cell cycle inhibitor associated with somatic cell senescence in
vitro, is induced in aged kidney, we studied whether kidneys with dysfunction and TA/IF
manifested increased p16 INK4a expression. We performed p16 INK4a immunostaining on …
tubular atrophy and interstitial fibrosis (TA/IF) without major glomerular abnormalities.
Somatic cell limitations could contribute to deterioration in aging and disease states. Since
expression of p16 INK4a, a cell cycle inhibitor associated with somatic cell senescence in
vitro, is induced in aged kidney, we studied whether kidneys with dysfunction and TA/IF
manifested increased p16 INK4a expression. We performed p16 INK4a immunostaining on …