A retinohypothalamic pathway in man: light mediation of circadian rhythms
Brain research, 1984•Elsevier
It has been proposed that, in animals, a retinohypothalamic pathway exists which mediates
the synchronization of the diurnal lightdark cycle with the central neural components
regulating endogenous rhythms. There have been numerous anatomic, physiologic and
behavioral investigations to substantiate this proposed connection in experimental animals.
Morphologic investigation of a retinohypothalamic tract in man has awaited the development
of a technique capable of axonal tracing in the human brain. The paraphenylenediamine …
the synchronization of the diurnal lightdark cycle with the central neural components
regulating endogenous rhythms. There have been numerous anatomic, physiologic and
behavioral investigations to substantiate this proposed connection in experimental animals.
Morphologic investigation of a retinohypothalamic tract in man has awaited the development
of a technique capable of axonal tracing in the human brain. The paraphenylenediamine …
Abstract
It has been proposed that, in animals, a retinohypothalamic pathway exists which mediates the synchronization of the diurnal lightdark cycle with the central neural components regulating endogenous rhythms. There have been numerous anatomic, physiologic and behavioral investigations to substantiate this proposed connection in experimental animals.
Morphologic investigation of a retinohypothalamic tract in man has awaited the development of a technique capable of axonal tracing in the human brain. The paraphenylenediamine method was applied to 7 post-mortem human brains. Degenerated axons were found in the suprachiasmatic nuclei of the hypothalamus in each of the 4 patients who had incurred prior optic nerve damage. The retinosuprachiasmatic pathway may be the anatomical substrate for the integration of retinal light information with endogenous rhythms in man.
Elsevier