The frequency of HLA class I alleles in Japanese patients with bone marrow failure
T Shichishima, H Noji, K Ikeda, K Akutsu… - …, 2006 - haematologica.org
T Shichishima, H Noji, K Ikeda, K Akutsu, Y Maruyama
Haematologica, 2006•haematologica.orgThe frequencies of the HLA-B* 4002 and HLA-A* 0206 alleles in patients with aplastic
anemia (AA)(n= 32; 21.9%) and paroxysmal nocturanl hemoglobinuria (PNH)(n= 24;
22.9%), respectively, were significantly different from those in controls (n= 371; 8.6%, p<
0.002 and 7.7%, p< 0.001, respectively), suggesting that each specific allele in AA or PNH
may be related to the immunologic pathophysiology of these disorders.
anemia (AA)(n= 32; 21.9%) and paroxysmal nocturanl hemoglobinuria (PNH)(n= 24;
22.9%), respectively, were significantly different from those in controls (n= 371; 8.6%, p<
0.002 and 7.7%, p< 0.001, respectively), suggesting that each specific allele in AA or PNH
may be related to the immunologic pathophysiology of these disorders.
Abstract
The frequencies of the HLA-B* 4002 and HLA-A* 0206 alleles in patients with aplastic anemia (AA)(n= 32; 21.9%) and paroxysmal nocturanl hemoglobinuria (PNH)(n= 24; 22.9%), respectively, were significantly different from those in controls (n= 371; 8.6%, p< 0.002 and 7.7%, p< 0.001, respectively), suggesting that each specific allele in AA or PNH may be related to the immunologic pathophysiology of these disorders.
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