Toosendanin and isotoosendanin suppress triple-negative breast cancer growth via inducing necrosis, apoptosis and autophagy
J Zhang, F Yang, X Mei, R Yang, B Lu, Z Wang… - Chemico-Biological …, 2022 - Elsevier
Toosendanin (TSN) and isotoosendanin (ITSN) are two natural triterpenoids isolated from
Fructus Meliae Toosendan or Cortex Meliae. This study aims to observe the inhibition of
TSN and ITSN on the growth of triple-negative breast cancer (TNBC) and the preliminary
engaged mechanism. Cell viability assay showed that both TSN and ITSN had obvious
cytotoxicity in a variety of tumor cells, and they had the best inhibitory effect on TNBC cells
including MDA-MB-231, BT549 and 4T1. Propidium iodide (PI) staining results showed the …
Fructus Meliae Toosendan or Cortex Meliae. This study aims to observe the inhibition of
TSN and ITSN on the growth of triple-negative breast cancer (TNBC) and the preliminary
engaged mechanism. Cell viability assay showed that both TSN and ITSN had obvious
cytotoxicity in a variety of tumor cells, and they had the best inhibitory effect on TNBC cells
including MDA-MB-231, BT549 and 4T1. Propidium iodide (PI) staining results showed the …
