The STATs of cancer—new molecular targets come of age
H Yu, R Jove - Nature Reviews Cancer, 2004 - nature.com
H Yu, R Jove
Nature Reviews Cancer, 2004•nature.comTumour cells acquire the ability to proliferate uncontrollably, resist apoptosis, sustain
angiogenesis and evade immune surveillance. STAT proteins—especially STAT3 and
STAT5—regulate all of these processes and are persistently activated in a surprisingly large
number of human cancers. Consequently, STAT proteins are emerging—unexpectedly—as
ideal targets for cancer therapy.
angiogenesis and evade immune surveillance. STAT proteins—especially STAT3 and
STAT5—regulate all of these processes and are persistently activated in a surprisingly large
number of human cancers. Consequently, STAT proteins are emerging—unexpectedly—as
ideal targets for cancer therapy.
Abstract
Tumour cells acquire the ability to proliferate uncontrollably, resist apoptosis, sustain angiogenesis and evade immune surveillance. STAT proteins — especially STAT3 and STAT5 — regulate all of these processes and are persistently activated in a surprisingly large number of human cancers. Consequently, STAT proteins are emerging — unexpectedly — as ideal targets for cancer therapy.
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