[PDF][PDF] The multifaceted role of perivascular macrophages in tumors
CE Lewis, AS Harney, JW Pollard - Cancer cell, 2016 - cell.com
CE Lewis, AS Harney, JW Pollard
Cancer cell, 2016•cell.comEvidence has emerged for macrophages in the perivascular niche of tumors regulating
important processes like angiogenesis, various steps in the metastatic cascade, the
recruitment and activity of other tumor-promoting leukocytes, and tumor responses to
frontline therapies like irradiation and chemotherapy. Understanding the mechanisms
controlling the recruitment, retention, and function of these cells could identify important
targets for anti-cancer therapeutics.
important processes like angiogenesis, various steps in the metastatic cascade, the
recruitment and activity of other tumor-promoting leukocytes, and tumor responses to
frontline therapies like irradiation and chemotherapy. Understanding the mechanisms
controlling the recruitment, retention, and function of these cells could identify important
targets for anti-cancer therapeutics.
Evidence has emerged for macrophages in the perivascular niche of tumors regulating important processes like angiogenesis, various steps in the metastatic cascade, the recruitment and activity of other tumor-promoting leukocytes, and tumor responses to frontline therapies like irradiation and chemotherapy. Understanding the mechanisms controlling the recruitment, retention, and function of these cells could identify important targets for anti-cancer therapeutics.
cell.com