The funny current in the context of the coupled-clock pacemaker cell system
VA Maltsev, EG Lakatta - Heart Rhythm, 2012 - heartrhythmjournal.com
Although spontaneous Ca2 release of yin is intrinsically stochastic, its potentially deleterious
unlimited regenerative nature is quenched by yang's induction of an AP, thus shifting yin
properties from stochasticity to periodicity. The yin periodicity is entrained by rhythmically
occurring APs of yang via rhythmically triggered depletion of the SR. Hence, during
spontaneous AP firing, the SR does not oscillate Ca2 independently, as it can in the
absence of the M clock, 1 but rather operates as a “stopwatch” to generate a timely crucial …
unlimited regenerative nature is quenched by yang's induction of an AP, thus shifting yin
properties from stochasticity to periodicity. The yin periodicity is entrained by rhythmically
occurring APs of yang via rhythmically triggered depletion of the SR. Hence, during
spontaneous AP firing, the SR does not oscillate Ca2 independently, as it can in the
absence of the M clock, 1 but rather operates as a “stopwatch” to generate a timely crucial …