[HTML][HTML] Autophagy in T cell function and aging
F Macian - Frontiers in Cell and Developmental Biology, 2019 - frontiersin.org
Frontiers in Cell and Developmental Biology, 2019•frontiersin.org
Dysregulation of autophagy with age has been identified as a central mechanism of aging
affecting many cells and tissues. T cells do also show decreased activity with age of different
autophagic pathways. Here, we will review the current knowledge of the different functions
that autophagy has in the regulation of T cell homeostasis, differentiation and function and
explore how the age-associated decreased in autophagy activity may contribute to the
altered T cell responses that characterize T cell immunosenescence.
affecting many cells and tissues. T cells do also show decreased activity with age of different
autophagic pathways. Here, we will review the current knowledge of the different functions
that autophagy has in the regulation of T cell homeostasis, differentiation and function and
explore how the age-associated decreased in autophagy activity may contribute to the
altered T cell responses that characterize T cell immunosenescence.
Dysregulation of autophagy with age has been identified as a central mechanism of aging affecting many cells and tissues. T cells do also show decreased activity with age of different autophagic pathways. Here, we will review the current knowledge of the different functions that autophagy has in the regulation of T cell homeostasis, differentiation and function and explore how the age-associated decreased in autophagy activity may contribute to the altered T cell responses that characterize T cell immunosenescence.
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