With the rapid development of stem cell-based gene therapies against HIV, there is pressing
requirement for an animal model to study the hematopoietic differentiation and immune
function of the genetically modified cells. The humanized Bone-marrow/Liver/Thymus (BLT)
mouse model allows for full reconstitution of a human immune system in the periphery,
which includes T cells, B cells, NK cells and monocytes. The human thymic implant also
allows for thymic selection of T cells in autologous thymic tissue. In addition to the study of …