Pathophysiology of acute respiratory distress syndrome and COVID-19 lung injury
KE Swenson, ER Swenson - Critical care clinics, 2021 - criticalcare.theclinics.com
Acute respiratory distress syndrome (ARDS) is a complex syndrome of acute lung injury
leading to noncardiogenic pulmonary edema from many causes that is heterogenous in its
clinical presentation and associated with a 40% mortality rate. 1 Extensive work since its
initial description in 1967 has elucidated biological pathways causing the many physiologic
changes of alveolar collapse/derecruitment, reduced lung compliance, greater pulmonary
vascular resistance, and gas exchange impairment that can be compounded by patient's …
leading to noncardiogenic pulmonary edema from many causes that is heterogenous in its
clinical presentation and associated with a 40% mortality rate. 1 Extensive work since its
initial description in 1967 has elucidated biological pathways causing the many physiologic
changes of alveolar collapse/derecruitment, reduced lung compliance, greater pulmonary
vascular resistance, and gas exchange impairment that can be compounded by patient's …