[HTML][HTML] Overview of follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells

S Haldar, H Agrawal, S Saha, AR Straughn… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
S Haldar, H Agrawal, S Saha, AR Straughn, P Roy, SS Kakar
International Journal of Biological Sciences, 2022ncbi.nlm.nih.gov
Follicle stimulating hormone (FSH) and its receptor (FSHR) have been reported to be
responsible for several physiological functions and cancers. The responsiveness of stem
cells and cancer stem cells towards the FSH-FSHR system make the function of FSH and its
receptors more interesting in the context of cancer biology. This review is comprised of
comprehensive information on FSH-FSHR signaling in normal physiology, gonadal stem
cells, cancer cells, and potential options of utilizing FSH-FSHR system as an anti-cancer …
Abstract
Follicle stimulating hormone (FSH) and its receptor (FSHR) have been reported to be responsible for several physiological functions and cancers. The responsiveness of stem cells and cancer stem cells towards the FSH-FSHR system make the function of FSH and its receptors more interesting in the context of cancer biology. This review is comprised of comprehensive information on FSH-FSHR signaling in normal physiology, gonadal stem cells, cancer cells, and potential options of utilizing FSH-FSHR system as an anti-cancer therapeutic target.
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