On macrophage diversity and inflammatory metabolic timers
PJ Murray - Nature Reviews Immunology, 2020 - nature.com
Nature Reviews Immunology, 2020•nature.com
Key papers were published in 2019 that solidify the notion that macrophage gene
expression is remarkably diverse; single-cell sequencing combined with new macrophage-
specific genetic tools has provided unexpected insights into the tissue-specific and
inflammatory diversity of macrophages. In addition, a new mechanism of inflammatory
control of macrophage diversity based on lactate-mediated histone modifications was
discovered.
expression is remarkably diverse; single-cell sequencing combined with new macrophage-
specific genetic tools has provided unexpected insights into the tissue-specific and
inflammatory diversity of macrophages. In addition, a new mechanism of inflammatory
control of macrophage diversity based on lactate-mediated histone modifications was
discovered.
Key papers were published in 2019 that solidify the notion that macrophage gene expression is remarkably diverse; single-cell sequencing combined with new macrophage-specific genetic tools has provided unexpected insights into the tissue-specific and inflammatory diversity of macrophages. In addition, a new mechanism of inflammatory control of macrophage diversity based on lactate-mediated histone modifications was discovered.
nature.com
