[HTML][HTML] Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux
CA Argmann, JY Edwards, CG Sawyez… - Journal of Biological …, 2005 - ASBMB
The cholesterol biosynthetic pathway produces numerous signaling molecules. Oxysterols
through liver X receptor (LXR) activation regulate cholesterol efflux, whereas the non-sterol
mevalonate metabolite, geranylgeranyl pyrophosphate (GGPP), was recently demonstrated
to inhibit ABCA1 expression directly, through antagonism of LXR and indirectly through
enhanced RhoA geranylgeranylation. We used HMG-CoA reductase inhibitors (statins) to
test the hypothesis that reduced synthesis of mevalonate metabolites would enhance …
through liver X receptor (LXR) activation regulate cholesterol efflux, whereas the non-sterol
mevalonate metabolite, geranylgeranyl pyrophosphate (GGPP), was recently demonstrated
to inhibit ABCA1 expression directly, through antagonism of LXR and indirectly through
enhanced RhoA geranylgeranylation. We used HMG-CoA reductase inhibitors (statins) to
test the hypothesis that reduced synthesis of mevalonate metabolites would enhance …