[HTML][HTML] Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages
Macrophage-specific Abca1 knock-out (Abca1–M/–M) mice were generated to determine the
role of macrophage ABCA1 expression in plasma lipoprotein concentrations and the innate
immune response of macrophages. Plasma lipid and lipoprotein concentrations in chow-fed
Abca1–M/–M and wild-type (WT) mice were indistinguishable. Compared with WT
macrophages, Abca1–M/–M macrophages had a> 95% reduction in ABCA1 protein, failed to
efflux lipid to apoA-I, and had a significant increase in free cholesterol (FC) and membrane …
role of macrophage ABCA1 expression in plasma lipoprotein concentrations and the innate
immune response of macrophages. Plasma lipid and lipoprotein concentrations in chow-fed
Abca1–M/–M and wild-type (WT) mice were indistinguishable. Compared with WT
macrophages, Abca1–M/–M macrophages had a> 95% reduction in ABCA1 protein, failed to
efflux lipid to apoA-I, and had a significant increase in free cholesterol (FC) and membrane …