Th1/17 cells, a subset of Th17 cells, are expanded in patients with active systemic lupus erythematosus
A Tsanaktsi, EE Solomou, SNC Liossis - Clinical Immunology, 2018 - Elsevier
Skewed cytokine production characterizes T cells in Systemic Lupus Erythematosus (SLE).
Among Th17 cells that are expanded in lupus, a subset (Th1/17) retains the ability to
produce IFNγ. We aimed to analyze Th17 and Th1/17 cells in patients with SLE. Patients
with active disease displayed increased percentages of circulating Τh17 and Th1/17 cells.
Stimulated T cells from patients with lupus secreted significantly more IL-17 compared to
healthy donors. Also, T cells from patients with active SLE released significantly lower levels …
Among Th17 cells that are expanded in lupus, a subset (Th1/17) retains the ability to
produce IFNγ. We aimed to analyze Th17 and Th1/17 cells in patients with SLE. Patients
with active disease displayed increased percentages of circulating Τh17 and Th1/17 cells.
Stimulated T cells from patients with lupus secreted significantly more IL-17 compared to
healthy donors. Also, T cells from patients with active SLE released significantly lower levels …