Circulating IFN-γ producing CD4+ T cells and IL-17A producing CD4+ T cells, HLA-shared epitope and ACPA may characterize the clinical response to therapy in …
N Alvandpur, R Tabatabaei, A Tahamoli-Roudsari… - Human immunology, 2020 - Elsevier
This study analyzed the association between peripheral distributions of helper T cell
subsets, HLA shared-epitope (SE), anti-cyclic citrullinated peptide antibody (ACPA) and
clinical response to therapy in rheumatoid arthritis (RA) patients. Frequencies of IFN-γ-
producing CD4+ T (Th1) and IL-17A-producing CD4+ T (Th17) cells were determined by
flow cytometry in 167 patients (114 cases with good-response (GR) and 53 poor-response
(PR) based on DAS28). HLA-DRB1 alleles for patients and 150 healthy controls were …
subsets, HLA shared-epitope (SE), anti-cyclic citrullinated peptide antibody (ACPA) and
clinical response to therapy in rheumatoid arthritis (RA) patients. Frequencies of IFN-γ-
producing CD4+ T (Th1) and IL-17A-producing CD4+ T (Th17) cells were determined by
flow cytometry in 167 patients (114 cases with good-response (GR) and 53 poor-response
(PR) based on DAS28). HLA-DRB1 alleles for patients and 150 healthy controls were …