Clinical and pathophysiological significance of the autoimmune response to citrullinated proteins in rheumatoid arthritis
M Sebbag, S Chapuy-Regaud, I Auger, E Petit-Texeira… - Joint Bone Spine, 2004 - Elsevier
Rheumatoid arthritis (RA) is the most frequent human autoimmune disease, affecting about
1% of the adult population worldwide. A better knowledge of the autoimmune mechanisms
involved is essential. We identified the epithelial targets of various autoantibodies
specifically associated to RA, as variants of (pro) filaggrin. We also showed that these
targets correspond to deiminated (“citrullinated”) proteins, of which arginyl residues have
been posttranslationally transformed into citrullyl residues by a peptidylarginine deiminase …
1% of the adult population worldwide. A better knowledge of the autoimmune mechanisms
involved is essential. We identified the epithelial targets of various autoantibodies
specifically associated to RA, as variants of (pro) filaggrin. We also showed that these
targets correspond to deiminated (“citrullinated”) proteins, of which arginyl residues have
been posttranslationally transformed into citrullyl residues by a peptidylarginine deiminase …