Inflammatory hypoxia: role of hypoxia-inducible factor

J Karhausen, VH Haase, SP Colgan - Cell Cycle, 2005 - Taylor & Francis
J Karhausen, VH Haase, SP Colgan
Cell Cycle, 2005Taylor & Francis
Sites of inflammation are characterized by significant changes in metabolic activity. Shifts in
energy supply and demand can result in diminished delivery and/or avai lability of oxygen,
leading to inflammation-associated tissue hypoxia and metabolic acidosis. These shifts in
tissue metabolism, as indicated by previous studies, are frequently associ ated with
vasculitis and profound recruitment of inflammatory cell types, particularly myeloid cells such
as neutrophils (PMN) and monocytes. Here, we review recent work addressing the influence …
Sites of inflammation are characterized by significant changes in metabolic activity. Shifts in energy supply and demand can result in diminished delivery and/or avai lability of oxygen, leading to inflammation-associated tissue hypoxia and metabolic acidosis. These shifts in tissue metabolism, as indicated by previous studies, are frequently associ ated with vasculitis and profound recruitment of inflammatory cell types, particularly myeloid cells such as neutrophils ( PMN) and monocytes.Here, we review recent work addressing the influence of hypoxia on development of inflammatory lesions, with particular emphasis on molecular pathways regulated by hypoxia-inducible factor (HIF).
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