Evidence-based update on rosacea comorbidities and their common physiologic pathways

AD Holmes, J Spoendlin, AL Chien, H Baldwin… - Journal of the American …, 2018 - Elsevier
Rosacea is a common chronic inflammatory disease affecting the facial skin whose etiology
and pathophysiology are the subject of much investigation. Risk factors include genetic and
environmental elements that may predispose individuals to localized inflammation and
abnormal neurovascular responses to stimuli. Recent studies have introduced an array of
systemic rosacea comorbidities, such as inflammatory bowel disease and neurologic
conditions, that can be challenging to synthesize. We critically review the current data …