Generation and Characterization of an Advillin-Cre Driver Mouse Line
S Zurborg, A Piszczek, C Martínez, P Hublitz… - Molecular …, 2011 - journals.sagepub.com
S Zurborg, A Piszczek, C Martínez, P Hublitz, MA Banchaabouchi, P Moreira, E Perlas…
Molecular pain, 2011•journals.sagepub.comProgress in the somatosensory field has been restricted by the limited number of genetic
tools available to study gene function in peripheral sensory neurons. Here we generated a
Cre-driver mouse line that expresses Cre-recombinase from the locus of the sensory neuron
specific gene Advillin. These mice displayed almost exclusive Cre-mediated recombination
in all peripheral sensory neurons. As such, the Advillin-Cre-driver line will be a powerful tool
for targeting peripheral neurons in future investigations.
tools available to study gene function in peripheral sensory neurons. Here we generated a
Cre-driver mouse line that expresses Cre-recombinase from the locus of the sensory neuron
specific gene Advillin. These mice displayed almost exclusive Cre-mediated recombination
in all peripheral sensory neurons. As such, the Advillin-Cre-driver line will be a powerful tool
for targeting peripheral neurons in future investigations.
Progress in the somatosensory field has been restricted by the limited number of genetic tools available to study gene function in peripheral sensory neurons. Here we generated a Cre-driver mouse line that expresses Cre-recombinase from the locus of the sensory neuron specific gene Advillin. These mice displayed almost exclusive Cre-mediated recombination in all peripheral sensory neurons. As such, the Advillin-Cre-driver line will be a powerful tool for targeting peripheral neurons in future investigations.
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