Inflammation induces an up-regulation of neuropeptide tyrosine (NPY) and its receptors in
the dorsal horn, suggesting an important role in nociceptive transmission. Our initial studies
revealed that NPY dose-dependently increased hotplate response latency, and to a lesser
degree, thermal paw withdrawal latency (PWL); these effects occurred at doses that affect
neither motor coordination (as assessed by the rotarod test) nor paw skin temperature. We
next evaluated the behavioral effects of intrathecal administration of NPY and NPY …