Neuropeptide Y actions and the distribution of Ca2+-dependent Cl− conductance in rat dorsal root ganglion neurons
FA Abdulla, PA Smith - Journal of the autonomic nervous system, 1999 - Elsevier
Neuropeptide Y (NPY) increases the excitability ofsmall', nociceptive, dorsal root ganglion
(DRG) neurons. This effect, which may contribute to the etiology ofneuropathic'pain, has
been attributed to attenuation of Ca2+-sensitive K+ conductance (s)(gK, Ca) following
suppression of Ca2+ entry via N-type Ca2+ channels. A problem arises with this conclusion
because rat DRG neurons normally contain high intracellular Cl− and some of them express
a Ca2+-dependent Cl− conductance (gCl, Ca). In this study, we find that in rat DRG neurons …
(DRG) neurons. This effect, which may contribute to the etiology ofneuropathic'pain, has
been attributed to attenuation of Ca2+-sensitive K+ conductance (s)(gK, Ca) following
suppression of Ca2+ entry via N-type Ca2+ channels. A problem arises with this conclusion
because rat DRG neurons normally contain high intracellular Cl− and some of them express
a Ca2+-dependent Cl− conductance (gCl, Ca). In this study, we find that in rat DRG neurons …