Translational control of chronic pain

OK Melemedjian, A Khoutorsky - Progress in molecular biology and …, 2015 - Elsevier
Pain is a crucial physiological response to injury and pathologies. The development and
maintenance of pain requires the expression of novel genes. The expression of such genes
occurs in highly regulated and orchestrated manner where protein translation provides an
exquisite temporal and spatial fidelity within the axons and dendrites of neurons. Signaling
pathways that regulate local translation are activated by cytokines, neurotrophic factors, or
neurotransmitters, which are released either due to tissue damage or neuronal activity. In …