Activation of mTOR in the spinal cord is required for pain hypersensitivity induced by chronic constriction injury in mice
W Zhang, XF Sun, JH Bo, J Zhang, XJ Liu… - Pharmacology …, 2013 - Elsevier
Background The mammalian target of rapamycin (mTOR) is known to regulate cell growth,
and it also participates in pain transmission as has been recently verified in inflammatory
and neuropathic pain models. The targeting of mTOR represents a new strategy for the
control of chronic pain. In the present study, we investigated the effect of mTOR in the
expression of PSD95 and NR2B-PSD95 or GluA2-PSD95 interaction ratio in a chronic
constriction injury (CCI) mice model. Methods Paw mechanical withdrawal threshold …
and it also participates in pain transmission as has been recently verified in inflammatory
and neuropathic pain models. The targeting of mTOR represents a new strategy for the
control of chronic pain. In the present study, we investigated the effect of mTOR in the
expression of PSD95 and NR2B-PSD95 or GluA2-PSD95 interaction ratio in a chronic
constriction injury (CCI) mice model. Methods Paw mechanical withdrawal threshold …