Gene editing of living cells is a cornerstone of present-day medical research that has
enabled scientists to address fundamental biologic questions and identify novel strategies to
treat diseases. The ability to manipulate adoptive cell therapy products has revolutionized
cancer immunotherapy and promises similar results for the treatment of autoimmune
diseases, inflammatory disorders, and transplant rejection. Clinical trials have recently
deemed polyclonal regulatory T (Treg) cell therapy to be a safe therapeutic option, but …