[HTML][HTML] Glycome diagnosis of human induced pluripotent stem cells using lectin microarray
Induced pluripotent stem cells (iPSCs) can now be produced from various somatic cell (SC)
lines by ectopic expression of the four transcription factors. Although the procedure has
been demonstrated to induce global change in gene and microRNA expressions and even
epigenetic modification, it remains largely unknown how this transcription factor-induced
reprogramming affects the total glycan repertoire expressed on the cells. Here we performed
a comprehensive glycan analysis using 114 types of human iPSCs generated from five …
lines by ectopic expression of the four transcription factors. Although the procedure has
been demonstrated to induce global change in gene and microRNA expressions and even
epigenetic modification, it remains largely unknown how this transcription factor-induced
reprogramming affects the total glycan repertoire expressed on the cells. Here we performed
a comprehensive glycan analysis using 114 types of human iPSCs generated from five …