[HTML][HTML] ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor
AT Holdbrooks, CM Britain, SL Bellis - Journal of Biological Chemistry, 2018 - ASBMB
Activation of the tumor necrosis factor receptor 1 (TNFR1) death receptor by TNF induces
either cell survival or cell death. However, the mechanisms mediating these distinct
outcomes remain poorly understood. In this study, we report that the ST6Gal-I
sialyltransferase, an enzyme up-regulated in numerous cancers, sialylates TNFR1 and
thereby protects tumor cells from TNF-induced apoptosis. Using pancreatic and ovarian
cancer cells with ST6Gal-I knockdown or overexpression, we determined that α2-6 …
either cell survival or cell death. However, the mechanisms mediating these distinct
outcomes remain poorly understood. In this study, we report that the ST6Gal-I
sialyltransferase, an enzyme up-regulated in numerous cancers, sialylates TNFR1 and
thereby protects tumor cells from TNF-induced apoptosis. Using pancreatic and ovarian
cancer cells with ST6Gal-I knockdown or overexpression, we determined that α2-6 …