[HTML][HTML] Emerging role of α2, 6-sialic acid as a negative regulator of galectin binding and function
Y Zhuo, SL Bellis - Journal of biological chemistry, 2011 - ASBMB
Galectins are β-galactoside-binding lectins that regulate diverse cell behaviors, including
adhesion, migration, proliferation, and apoptosis. Galectins can be expressed both
intracellularly and extracellularly, and extracellular galectins mediate their effects by
associating with cell-surface oligosaccharides. Despite intensive current interest in
galectins, strikingly few studies have focused on a key enzyme that acts to inhibit galectin
signaling, namely β-galactoside α2, 6-sialyltransferase (ST6Gal-I). ST6Gal-I adds an α2, 6 …
adhesion, migration, proliferation, and apoptosis. Galectins can be expressed both
intracellularly and extracellularly, and extracellular galectins mediate their effects by
associating with cell-surface oligosaccharides. Despite intensive current interest in
galectins, strikingly few studies have focused on a key enzyme that acts to inhibit galectin
signaling, namely β-galactoside α2, 6-sialyltransferase (ST6Gal-I). ST6Gal-I adds an α2, 6 …