Genomic organization of the interleukin-1 locus
SL Taylor, BR Renshaw, KE Garka, DE Smith, JE Sims - Genomics, 2002 - Elsevier
SL Taylor, BR Renshaw, KE Garka, DE Smith, JE Sims
Genomics, 2002•ElsevierRecent additions have expanded the interleukin (IL)-1 gene family to 10 members. We have
determined the order, orientation, and intergenic distance of the nine IL-1 family genes that
lie on human chromosome 2. We report cDNA sequences for the mouse orthologs of three of
these genes. The order and orientation of the mouse genes have been mapped, and the
mouse locus compared with the human locus. There is a break in the mouse locus of> 100
kb, compared with the human locus, located between Il1b and the most centromere-proximal …
determined the order, orientation, and intergenic distance of the nine IL-1 family genes that
lie on human chromosome 2. We report cDNA sequences for the mouse orthologs of three of
these genes. The order and orientation of the mouse genes have been mapped, and the
mouse locus compared with the human locus. There is a break in the mouse locus of> 100
kb, compared with the human locus, located between Il1b and the most centromere-proximal …
Recent additions have expanded the interleukin (IL)-1 gene family to 10 members. We have determined the order, orientation, and intergenic distance of the nine IL-1 family genes that lie on human chromosome 2. We report cDNA sequences for the mouse orthologs of three of these genes. The order and orientation of the mouse genes have been mapped, and the mouse locus compared with the human locus. There is a break in the mouse locus of > 100 kb, compared with the human locus, located between Il1b and the most centromere-proximal of the novel mouse genes. The mouse seems to be missing an ortholog of human IL1F7.
Elsevier