Fatal varicella associated with selective natural killer cell deficiency

A Etzioni, C Eidenschenk, R Katz, R Beck… - The Journal of …, 2005 - Elsevier
A Etzioni, C Eidenschenk, R Katz, R Beck, JL Casanova, S Pollack
The Journal of pediatrics, 2005Elsevier
A 2-year-old girl with recurrent severe varicella infections had a fatal outcome. Studies of
cellular and humoral immunity were normal. No natural killer (NK) cells were detected, and
NK activity was markedly decreased. The interleukin (IL) 15/IL15R signaling pathway was
intact. This case emphasizes the role of NK cells in controlling herpes viral infection.
A 2-year-old girl with recurrent severe varicella infections had a fatal outcome. Studies of cellular and humoral immunity were normal. No natural killer (NK) cells were detected, and NK activity was markedly decreased. The interleukin (IL)15/IL15R signaling pathway was intact. This case emphasizes the role of NK cells in controlling herpes viral infection.
Elsevier