Cubilin is an endocytic receptor highly expressed in renal proximal tubules, where it
mediates uptake of albumin and filtered forms of apoA-I/HDL. Cubilin deficiency leads to
urinary loss of albumin and apoA-I; however, the consequences of cubilin loss on the
homeostasis of blood albumin and apoA-I/HDL have not been studied. Using mice
heterozygous for cubilin gene deletion (cubilin HT mice), we show that cubilin
haploinsufficiency leads to reduced renal proximal tubular uptake of albumin and apoA-I …