Dual function of Langerhans cells in skin TSLP-promoted TFH differentiation in mouse atopic dermatitis
P Marschall, R Wei, J Segaud, W Yao, P Hener… - Journal of Allergy and …, 2021 - Elsevier
Background Atopic dermatitis (AD) is among the most common chronic inflammatory skin
diseases, usually occurring early in life, and often preceding other atopic diseases such as
asthma. TH 2 has been believed to play a crucial role in cellular and humoral response in
AD, but accumulating evidence has shown that follicular helper T cell (T FH), a critical player
in humoral immunity, is associated with disease severity and plays an important role in AD
pathogenesis. Objectives This study aimed at investigating how T FH s are generated during …
diseases, usually occurring early in life, and often preceding other atopic diseases such as
asthma. TH 2 has been believed to play a crucial role in cellular and humoral response in
AD, but accumulating evidence has shown that follicular helper T cell (T FH), a critical player
in humoral immunity, is associated with disease severity and plays an important role in AD
pathogenesis. Objectives This study aimed at investigating how T FH s are generated during …