Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies

DR Lemos, JS Duffield - Science translational medicine, 2018 - science.org
DR Lemos, JS Duffield
Science translational medicine, 2018science.org
Recent scientific findings support the notion that fibrosis is driven by tissue-specific cellular
and molecular mechanisms. Analysis of seemingly equivalent mesenchymal stromal cell
(MSC) populations residing in different organs revealed unique properties and lineage
capabilities that vary from one anatomical location to another. We review recently
characterized tissue-resident MSC populations with a prominent role in fibrosis and highlight
therapeutically relevant molecular pathways regulating their activity in chronic disease.
Recent scientific findings support the notion that fibrosis is driven by tissue-specific cellular and molecular mechanisms. Analysis of seemingly equivalent mesenchymal stromal cell (MSC) populations residing in different organs revealed unique properties and lineage capabilities that vary from one anatomical location to another. We review recently characterized tissue-resident MSC populations with a prominent role in fibrosis and highlight therapeutically relevant molecular pathways regulating their activity in chronic disease.
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