Human immunodeficiency virus-infected monocyte-derived macrophages express surface gp120 and fuse with CD4 lymphoid cells in vitro: a possible mechanism of T …
Monocyte-derived macrophages (MDM) infected in vitro with a macrophage-tropic strain of
human immunodeficiency virus (HIV) fused with uninfected, CD4-expressing T
lymphoblastoid cells, but not with a subclone of these cells lacking surface CD4. Infected
MDM also fused with uninfected autologous and heterologous MDM. Recombinant soluble
CD4 protein (rsCD4)(10 μg/ml) and full-length recombinant glycosylated gp120 (20 μg/ml)
each inhibited fusion by 94–99%; the inhibition was dose-dependent. The N-terminal portion …
human immunodeficiency virus (HIV) fused with uninfected, CD4-expressing T
lymphoblastoid cells, but not with a subclone of these cells lacking surface CD4. Infected
MDM also fused with uninfected autologous and heterologous MDM. Recombinant soluble
CD4 protein (rsCD4)(10 μg/ml) and full-length recombinant glycosylated gp120 (20 μg/ml)
each inhibited fusion by 94–99%; the inhibition was dose-dependent. The N-terminal portion …