The Majority of Freshly Sorted Simian Immunodeficiency Virus (SIV)-Specific CD8+ T Cells Cannot Suppress Viral Replication in SIV-Infected Macrophages
L Vojnov, MA Martins, AT Bean… - Journal of …, 2012 - Am Soc Microbiol
L Vojnov, MA Martins, AT Bean, MG Veloso de Santana, JB Sacha, NA Wilson, MC Bonaldo…
Journal of virology, 2012•Am Soc MicrobiolHuman immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) primarily
infect activated CD4+ T cells but can infect macrophages. Surprisingly, ex vivo tetramer-
sorted SIV-specific CD8+ T cells that eliminated and suppressed viral replication in SIV-
infected CD4+ T cells failed to do so in SIV-infected macrophages. It is possible, therefore,
that while AIDS virus-infected macrophages constitute only a small percentage of all virus-
infected cells, they may be relatively resistant to CD8+ T cell-mediated lysis and continue to …
infect activated CD4+ T cells but can infect macrophages. Surprisingly, ex vivo tetramer-
sorted SIV-specific CD8+ T cells that eliminated and suppressed viral replication in SIV-
infected CD4+ T cells failed to do so in SIV-infected macrophages. It is possible, therefore,
that while AIDS virus-infected macrophages constitute only a small percentage of all virus-
infected cells, they may be relatively resistant to CD8+ T cell-mediated lysis and continue to …
Abstract
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) primarily infect activated CD4+ T cells but can infect macrophages. Surprisingly, ex vivo tetramer-sorted SIV-specific CD8+ T cells that eliminated and suppressed viral replication in SIV-infected CD4+ T cells failed to do so in SIV-infected macrophages. It is possible, therefore, that while AIDS virus-infected macrophages constitute only a small percentage of all virus-infected cells, they may be relatively resistant to CD8+ T cell-mediated lysis and continue to produce virus over long periods of time.
American Society for Microbiology