[HTML][HTML] IRF4-dependent dendritic cells regulate CD8+ T-cell differentiation and memory responses in influenza infection
Acute respiratory disease caused by influenza viruses is imperfectly mitigated by annual
vaccination to select strains. Development of vaccines that elicit lung-resident memory CD8+
T cells (T RM) would offer more universal protection to seasonal and emerging pandemic
viruses. Understanding how lung-resident dendritic cells (DCs) regulate T RM differentiation
would be an important step in this process. Here, we used CD11c-cre-Irf4 f/f (KO) mice,
which lack lung-resident IRF4-dependent CD11b+ CD24 hi DCs and show IRF4 deficiency …
vaccination to select strains. Development of vaccines that elicit lung-resident memory CD8+
T cells (T RM) would offer more universal protection to seasonal and emerging pandemic
viruses. Understanding how lung-resident dendritic cells (DCs) regulate T RM differentiation
would be an important step in this process. Here, we used CD11c-cre-Irf4 f/f (KO) mice,
which lack lung-resident IRF4-dependent CD11b+ CD24 hi DCs and show IRF4 deficiency …