[HTML][HTML] Lung-resident CD4+ T cells are sufficient for IL-4Rα-dependent recall immunity to Nippostrongylus brasiliensis infection
Immunity to Nippostrongylus brasiliensis reinfection requires pulmonary CD4+ T-cell
responses. We examined whether secondary lymphoid recruited or pre-existing lung CD4+
T-cell populations coordinated this immunity. To do this, we blocked T-cell egress from
lymph nodes using Fingolimod (FTY720). This impaired host ability to resolve a primary
infection but did not change effectiveness of recall immunity. Associated with this effective
recall immunity was the expansion and T helper type 2 polarization of a pre-existing …
responses. We examined whether secondary lymphoid recruited or pre-existing lung CD4+
T-cell populations coordinated this immunity. To do this, we blocked T-cell egress from
lymph nodes using Fingolimod (FTY720). This impaired host ability to resolve a primary
infection but did not change effectiveness of recall immunity. Associated with this effective
recall immunity was the expansion and T helper type 2 polarization of a pre-existing …